LIST：

Functional Ingredients
Product Name	Active Ingredient			Description
	INCI	CAS	EINECS
Sunpu®Allantoin	Allantoin	97-59-6	202-592-8	White crystalline powder. Cosmetic Grade: 98.0～103.0% Pharmaceutic Grade: 98.5～101.0%; conforms to USP and Ph. Eur.

 

Personal Care Preservatives
Product Name	Active Ingredient			Description
	INCI	CAS	EINECS
SupGuard® GM-A	Diazolidinyl Urea	78491-02-8	278-928-2	White, fine, free-flowing powder
SupGuard®     GM-115	Imidazolidinyl Urea	39236-46-9	254-372-6	White, fine, free-flowing powder
SupGuard® GM-B	Diazolidinyl Urea Methylparaben Propylparaben	78491-02-8 99-76-3 94-13-3	278-928-2 202-785-7 202-307-7	Colorless to light yellow clear viscous liquid. For formulations with 75% or higher water content
SupGuard® GM-BE	Diazolidinyl Urea Methylparaben Propylparaben	78491-02-8 99-76-3 94-13-3	278-928-2 202-785-7 202-307-7	Colorless to light yellow clear viscous liquid. For emulsion systems with oil phases greater than 25%
SupGuard® GM-P	Diazolidinyl Urea Iodopropynyl Butylcarbamate	78491-02-8 55406-53-6	278-928-2 259-627-5	White, fine, free-flowing powder
SupGuard® GM-BP	Diazolidinyl Urea Iodopropynyl Butylcarbamate	78491-02-8 55406-53-6	278-928-2 259-627-5	Colorless to light yellow clear viscous liquid
SupGuard® GM-C	Diazolidinyl Urea Methylparaben Iodopropynyl Butylcarbamate	78491-02-8 99-76-3 55406-53-6	278-928-2 202-785-7 259-627-5	Colorless to light yellow clear viscous liquid
SupGuard® K15	Methylchloroisothiazolinone Methylisothiazolinone	26172-55-4 2682-20-4	247-500-7 220-239-6	≥1.5% a.i.. Clear liquid. Magnesium salt stabilized
SupGuard® MIT	Methylisothiazolinone	2682-20-4	220-239-6	≥9.5% a.i.. Clear liquid
SupGuard® G	DMDM Hydantoin	6440-58-0	229-222-8	55% a.i.. Colorless clear liquid
SupGuard® LGP	DMDM Hydantoin Iodopropynyl Butylcarbamate Methylisothiazolinone	6440-58-0 55406-53-6 2682-20-4	229-222-8 259-627-5 220-239-6	Colorless clear liquid
SupGuard® HG	Sodium Hydroxymethylglycinate	70161-44-3	274-357-8	50% a.i.. Colorless to light yellow clear liquid
SupGuard® IPBC-I	Iodopropynyl Butylcarbamate	55406-53-6	259-627-5	≥99% a.i.. White crystalline powder
SupGuard® IPBC-II	Iodopropynyl Butylcarbamate	55406-53-6	259-627-5	6% a.i.. Viscous liquid. Water soluble and especially for high aqueous formulations
SupGuard® IPBC-III	Phenoxyethanol Iodopropynyl Butylcarbamate	122-99-6 55406-53-6	204-589-7 259-627-5	Light yellow clear liquid. Especially for high oil phase formulations and anhydrous systems
SupGuard® PE10	Phenoxyethanol	122-99-6	204-589-7	≥99% a.i.. Colorless clear liquid
SupGuard® PE51	Phenoxyethanol Methylparaben Ethylparaben Propylparaben Butylparaben Isobutylparaben	122-99-6 99-76-3 120-47-8 94-13-3 94-26-8 4247-02-3	204-589-7 202-785-7 204-399-4 202-307-7 202-318-7 224-208-8	Colorless to light yellow viscous liquid
SupGuard® BN	2-Bromo-2-nitropropane-1,3-diol	52-51-7	200-143-0	≥99% a.i.. White or almost white crystalline powder
SupGuard® NP-M	Methylparaben	99-76-3	202-785-7	≥99% a.i.. White crystalline powder
SupGuard® NP-E	Ethylparaben	120-47-8	204-399-4	≥99% a.i.. White crystalline powder
SupGuard® NP-P	Propylparaben	94-13-3	202-307-7	≥99% a.i.. White crystalline powder
SupGuard® NP-B	Butylparaben	94-26-8	202-318-7	≥99% a.i.. White or almost white crystalline powder
SupGuard® NP-IB	Isobutylparaben	4247-02-3	224-208-8	≥99% a.i.. White or almost white crystalline powder
SupGuard® NP-IP	Isopropylparaben	4191-73-5	224-069-3	≥99% a.i.. White or almost white crystalline powder
SupGuard® NP-Oil	Isopropylparaben Isobutylparaben Butylparaben	4191-73-5 4247-02-3 94-26-8	224-069-3 224-208-8 202-318-7	≥97% total parabens. Solvent-free, light yellow, clear stable viscous liquid. Especially for high oil phase formulations and anhydrous systems
SupGuard® BC	Benzethonium Chloride	121-54-0	204-479-9	≥97% a.i.. White or almost white crystalline powder
SupGuard® BC200	Benzethonium Chloride	121-54-0	204-479-9	Synergistic formulation. Clear viscous liquid. Especially for hygienic wipes.
Triclosan-I	Triclosan	3380-34-5	222-182-2	≥99% a.i.. White crystalline powder
Triclosan-II	Triclosan	3380-34-5	222-182-2	10% a.i.. Viscous liquid. Water soluble and especially for high aqueous formulations

 

Industrial Biocides
Product Name	Active Ingredient			Description
	INCI	CAS	EINECS
SupBio® MP31	Formulation	――	――	Special for metalworking fluids. Especially for water-based systems
SupBio® K15	Methylchloroisothiazolinone Methylisothiazolinone	26172-55-4 2682-20-4	247-500-7 220-239-6	≥1.5% a.i.. Clear Liquid. Copper salt stabilized
SupBio® W140	Methylchloroisothiazolinone Methylisothiazolinone	26172-55-4 2682-20-4	247-500-7 220-239-6	≥14.0% a.i.. Clear Liquid. Magnesium salt stabilized

 

Functional Wipe Concentrates
Product Name	Active Ingredient			Description
	INCI	CAS	EINECS
SupClean®BW	Formulation	――	――	Special for glass. Easy to remove grease, dirt, stains and finger marks. Quick drying, streak-free and anti-fog

 

 

Sunpu® Allantoin

DESCRIPTION

 

INCI:	Allantoin
CAS:	97-59-6
EINECS:	202-592-8
Molecular Formula:	C4H6N4O3
Molecular Weight:	158.12

 

 

 

Structural                   Formula:  

 

Synonyms:

5-Ureidohydantoin; Glyoxylic acid diureide; 2,5-Dioxo-4-imidazolidinyl urea

 

SPECIFICATIONS (Not Necessarily)

Properties	Cosmetic Grade	Pharmaceutic Grade*
Appearance	White crystalline powder	White crystalline powder
Odor	Odorless	Odorless
Identification   (a) IR Spectrum	-	Conforms
(b) TLC Test	-	Conforms
Content	98.0-103.0%	98.5-101.0%
Melting Point (with decomposition)	223℃ min.	225℃ min.
Loss on Drying	0.5% max.	0.1% max.
Residue on Ignition	0.5% max.	0.1% max.
pH (0.5% in water, 25℃)	4.0-6.0	-
Acidity or Alkalinity	-	Conforms
Optical Rotation	-	Conforms
Reducing Substances	-	Conforms
Related Substances	-	Conforms
As	0.0002% max.	0.0002% max.
Pb	0.001% max.	0.001% max.

 

* Conforms to USP and Ph. Eur.

 

PACKAGING

Standard packaging includes the following:

1.0kg/bottle; 10bottles/box

20 kg net weight cardboard drum inside plastic bag sealed

Other package sizes are available upon request.

 

STORAGE

Store in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use.

 

PERIOD OF VALIDITY

24 months

 

PROPERTIES

Solubility

Solubility in water increases obviously with increasing temperature (5.7g/L at 25℃；11g/L at 40℃；40g/L at 75℃).

Slightly soluble in propylene glycol (3g/L at 25℃).

Very slightly soluble in ethanol (0.4g/L at 25℃) and glycerin (0.15g/L at 25℃).

 

Biological Activity

Allantoin promotes wound healing, speeds up cell regeneration, and has a keratolytic effect. It produces its desirable effects by promoting and speeding up the healthy, natural processes of the body. It helps the skin to help itself.

 

Toxicological Data

Acute oral toxicity LD50 (rats):	>5000mg/kg
Eye irritation (rabbits):	No irritation
Skin irritation:	Non-irritating at normal use levels

 

REGULATORY STATUS

In the USA:	Not restricted in any way if used as a cosmetic ingredient. Classified by the FDA as a Category I (safe and effective), OTC drug (skin protectant) if used as an active ingredient.
In the EU: (76/768/EEC)	No direct regulations. No limitations; permitted for cosmetic use.
In Japan:	Not specifically regulated according to the Standards for Cosmetics, enacted by the Ministry of Health, Labour and Welfare.

 

 

 

 APPLICATIONS

 

In pharmaceuticals and dermatology, allantoin is used in the treatment of ulcers, slow-healing wounds and burns. Addition of it to wound ointments and healing compositions promotes wound cleansing and healing. Allantoin has been classified by the US FDA OTC Topical Analgesic Review Panel as a Category I active ingredient (skin protectant), at use-levels of 0.5-2.0%. The FDA approved applications include minor cuts, scrapes, burns, sunburn, fever blisters, diaper rash and chafed, chapped, cracked or wind burned skin and lips.

In cosmetics, allantoin is used in numerous preparations, where it enhances cell renewal, skin soothing, skin moisturizing, cleansing and healing action. In addition, it has the advantages of being non-toxic, non-irritating and effective in low concentrations. Allantoin promotes cell regeneration in skin exposed to and weakened by environmental factors, and helps to promote and maintain the health of intact skin on the body and face. Addition of it to hand lotions and hand creams helps eliminate rough, chapped skin, and leaves hands smooth and soft. In hair care, because of its extraordinarily good keratolytic properties, allantoin is a valuable additive in various products such as shampoos and hair gels, especially for the treatment of dandruff. Allantoin has been incorporated into various lotions and creams, lipsticks, aftershave balms, suntan products, bath foams, baby products and various aerosol preparations. It has also been used in oral hygiene products such as toothpaste and mouthwash. Its good compatibility with most relevant materials also allows it to be easily incorporated into existing formulations.

The recommended use level in cosmetics is 0.1-0.5%.

The information in this document corresponds to the present state of our knowledge and is intended to describe our products and their possible applications. No warranty is either expressed or implied. The values given are recommended guides. All responsibility for determining the most effective use-level remains with the final product manufacturer.

 

 

SupGuard GM-115 (Imidazolidinyl Urea )

INCI Adopted Name:Imidazolidinyl Urea 
CAS Registry No.:39236-46-9
Molecular Formula:C11H16N8O8 
Molecular Weight:388.30 
Structural Formula:
Synonyms:N,N"-methylenebis[N'-(3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl)] Urea; 3,3'-Bis(1-hydroxymethyl-2,5-dioxoimidazolidin-4-yl)-1,1'- methylenediurea

SPECIFICATIONS (Not Necessarily) 
AppearanceWhite, fine, free-flowing powder
OdorOdorless or slight characteristic odor 
Nitrogen26.0-28.0% 
Loss on Drying3.0% max. 
Residue on Ignition3.0% max.
pH (1% in water)6.0-7.5 
As0.001% max.
 Pb0.004% max.

PACKAGING 
Standard packaging includes the following:
1.0kg/bottle; 10bottles/box 
20 kg net weight cardboard drum inside plastic bag sealed Other package sizes are available upon request. 

STORAGE 
Store in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use. 

PERIOD OF VALIDITY
24 months 

PROPERTIES 
Solubility
Very soluble in water; freely soluble in propylene glycol and glycerin; 
slightly soluble in methanol and ethanol; not soluble in mineral oil.

Antimicrobial Activity 
SupGuard GM-115 is very effective against Gram-negative bacteria, including Pseudomonas aeruginosa. It acts synergistically with other preservatives. In combination with Parabens and/or Iodopropynyl Butylcarbamate (IPBC), SupGuard GM-115 provides a complete antimicrobial preservative system that is active against bacteria, yeast and mold. 

Toxicological Data 
Acute oral toxicity LD50 rats):5000mg/kg Acute dermal toxicity LD50 (rabbits):>8000mg/kg 
Eye irritation (rabbits):Non-irritating at 5% aqueous solution 
Primary skin irritation (rabbits):Non-irritating at 5% aqueous solution 

Applications 
The active ingredient of SupGuard GM-115, Imidazolidinyl Urea, is permanently listed by the EU at levels up to 0.6% without restrictions. It is one of the most widely used cosmetic preservatives in the world. 
SupGuard GM-115 is an effective antibacterial preservative in a wide range of liquid and powder type cosmetic products. It is compatible with essentially all cosmetic ingredients, such as surfactants, proteins, and other special ingredients. As a result of its high solubility in water, 
SupGuard GM-115 can be successfully incorporated into cold mix formulations. It is safe and effective for both leave-on and rinse-off products. The recommended use level is 0.2-0.4%. 

The information in this publication corresponds to the present state of our knowledge and is intended to describe our products and their possible applications. 
No warranty is either expressed or implied. Every cosmetic formulation requires a tailormade preservative system to meet its special needs. 

Every developed or modified product should be challenge tested to assure preservative efficacy.

 

SupGuard GM-A(Diazolidinyl Urea )

INCI Adopted Name:Diazolidinyl Urea 
CAS Registry No.:78491-02-8 
Molecular Formula:C8H14N4O7 
Molecular Weight:278.22 
Structural Formula: 
Synonyms:N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'- bis(hydroxymethyl)urea; N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)- N'-(hydroxymethyl)urea 

SPECIFICATIONS (Not Necessarily) 
AppearanceWhite, fine, free-flowing powder 
OdorOdorless or slight characteristic odor 
Nitrogen19.0-21.0%
Loss on Drying3.0% max. 
Residue on Ignition3.0% max. 
pH (1% in water)6.0-8.0
As0.001% max. 
Pb0.004% max. 

PACKAGING 
Standard packaging includes the following: 
1.0kg/bottle; 10bottles/box 
20 kg net weight cardboard drum inside plastic bag sealed 
Other package sizes are available upon request. 

STORAGE
Store in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use. 

PERIOD OF VALIDITY
24 months 

PROPERTIES 
Solubility 
Very soluble in water; freely soluble in propylene glycol and glycerin; 
slightly soluble in methanol and ethanol; not soluble in mineral oil.

Antimicrobial Activity 
SupGuard GM-A provides a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, including Pseudomonas species; and some protection against yeast and mold. 

Toxicological Data
Acute oral toxicity LD50 (mice):3200mg/kg
Eye irritation (rabbits):Non-irritating at 3% aqueous solution 
Primary skin irritation (rabbits):Non-irritating at 3% aqueous solution 

Applications 
The active ingredient of SupGuard GM-A, Diazolidinyl Urea, is permanently listed by the EU at levels up to 0.5% without restrictions. 
SupGuard GM-A is safe for both leave-on and rinse-off products and provides effective protection at low concentration levels. It is typically used at concentrations from 0.1-0.3%. 
SupGuard GM-A is compatible with virtually all cosmetic ingredients. It is not inactivated by emulsifiers, proteins or other ingredients that affect other preservative materials.
SupGuard GM-A is an excellent preservative for shampoos and hair conditioners. It is synergistic with other preservative materials, especially parabens and/or Iodopropynyl Butylcarbamate (IPBC). This combination is a complete cosmetic preservative systems that is effective at protecting well formulated products from bacterial, yeast and mold contamination during use. The activity against yeast and mold does not decrease while SupGuard GM-A is used in combination with parabens even when paraben effectiveness has been diminished by interaction with nonionics or proteins, or migration into the oil phase. 

The information in this publication corresponds to the present state of our knowledge and is intended to describe our products and their possible applications. 
No warranty is either expressed or implied. Every cosmetic formulation requires a tailormade preservative system to meet its special needs. 

Every developed or modified product should be challenge tested to assure preservative efficacy.

 

 SupGuard K15

 

SupGuard K15 is a liquid preservative system with the following active ingredients:

 

INCI Adopted Name	Structural Formula	CAS Registry No.
Methylchloroisothiazolinone		26172-55-4
Methylisothiazolinone		2682-20-4

 

Like Product Name:  Kathon CG

 

SPECIFICATIONS (Not Necessarily)

Appearance	Light amber clear liquid
Odor	Characteristically mild
Active Ingredients	1.5% min.
Magnesium Salts (nitrate and chloride)	21-24%
Specific Gravity(20℃)	1.19-1.21
pH	2.5-4.0
As	0.001% max.
Pb	0.004% max.

 

PACKAGING

Standard packaging includes the following:

1.0kg/bottle; 10bottles/box

20kg net weight plastic pail

220kg net weight plastic drum

Other package sizes are available upon request.

 

STORAGE

Store in a well-ventilated, cool area, out of direct sunlight. Keep containers tightly closed when not in use.

 

PERIOD OF VALIDITY

12 months since the date of manufacture

 

PROPERTIES

Solubility

Completely soluble in water; soluble in lower alcohols and glycols.

 

Antimicrobial Activity

SupGuard K15 has extremely broad spectrum activity against Gram-positive and Gram-negative bacteria, molds and yeasts. It can be used to make high performance bactericides.

 

Toxicological Data

Acute oral toxicity LD50 (mice):	3160mg/kg (female),  3480mg/kg (male)
Acute dermal toxicity LD50 (rabbits):	﹥5000mg/kg
Eye irritation (rabbits):	Non-irritating at 0.5% aqueous solution
Primary skin irritation (rabbits):	Non-irritating at 0.5% aqueous solution

 

Applications in Cosmetics

The active ingredients of SupGuard K15 are globally approved as a safe, effective preservative for rinse-off products such as shampoos and conditioners. It is listed in the USA and the EU respectively as an approved cosmetic preservative at levels up to 0.0015% of active ingredients.

SupGuard K15 does not bioaccumulate. It is biodegradable and degrades rapidly to non-toxic, non-persistent substances in the environment. SupGuard K15 is effective and stable up to pH8. It is generally compatible with most components of formulations. However, the presence of a few agents such as thiols, mercaptans, secondary amines, sulfides and other nucleophiles will cause degradation of the active ingredients. Conditions of temperatures in excess of 50℃ for long periods of time and pH above 8 will lead to loss of activity.

The maximum recommended use level is 0.1% by weight of product as supplied in rinse-off products and 0.05% in leave-on products.

 

  

 

 

SupGuard® GM-B

SupGuard® GM-B is a liquid preservative system with the following composition:

INCI	Structural Formula	CAS	EINECS
Diazolidinyl Urea		78491-02-8	278-928-2
Methylparaben		99-76-3	202-785-7
Propylparaben		94-13-3	202-307-7
Propylene Glycol		57-55-6	200-338-0

 

 

TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	Colorless to light yellow clear viscous liquid
Odor	Characteristically mild
Nitrogen	5.4-6.8%
Methylparaben	11%
Propylparaben	3%
Specific Gravity(20℃)	1.16-1.19
Residue on Ignition	0.8% max.
Total Solids	42.5-45.5%
As	0.0003% max.
Pb	0.001% max.

 

 

 

 

SupGuard®  GM-P

SupGuard® GM-BP is a liquid preservative system with the following composition:

INCI	Structural Formula	CAS	EINECS
Diazolidinyl Urea		78491-02-8	278-928-2
Iodopropynyl Butylcarbamate		55406-53-6	259-627-5
Propylene Glycol		57-55-6	200-338-0

 

TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	Colorless to slight yellow clear viscous liquid
Odor	Characteristically mild
Color (Hazen)	50 max.
Nitrogen	7.5-8.5%
IPBC	0.35-0.55%
Specific Gravity(20℃)	1.15-1.25
Residue on Ignition	1.5% max.
As	0.0003% max.
Pb	0.001% max.

 

 

SupGuard®  GM-P

SupGuard® GM-P is a broad spectrum, non-paraben preservative system with the following composition:

INCI	Structural Formula	CAS	EINECS
Diazolidinyl Urea		78491-02-8	278-928-2
Iodopropynyl Butylcarbamate		55406-53-6	259-627-5

 

TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	White, fine, free-flowing powder
Odor	Characteristically mild
Nitrogen	19.0-21.0%
IPBC	0.75-1.25%
Loss on Drying	3.0% max.
Residue on Ignition	3.0% max.
pH (1% in water)	6.0-7.5
As	0.0003% max.
Pb	0.001% max.

 

 

 

 

SupGuard®  PE51

SupGuard® PE51 is a liquid preservative system with the following active ingredients:

INCI	Structural Formula	CAS	EINECS
Phenoxyethanol		122-99-6	204-589-7
Methylparaben		99-76-3	202-785-7
Ethylparaben		120-47-8	204-399-4
Propylparaben		94-13-3	202-307-7
Butylparaben		94-26-8	202-318-7
Isobutylparaben		4247-02-3	224-208-8

 

 

TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	Colorless to light yellow, clear liquid
Odor	Characteristically mild
Specific Gravity(25℃)	1.11-1.14
Refractive Index	1.538-1.545
Total Parabens	28-32%
As	0.0003% max.
Pb	0.001% max.

 

 

 

 

SupGuard G(DMDM Hydantoin)

 

INCI Adopted Name:	DMDM Hydantoin
CAS Registry No.:	6440-58-0
Molecular Formula:	C7H12N2O4
Molecular Weight:	188.18

 

Structural Formula:

Like Product Name:

Glydant

 

SPECIFICATIONS (Not Necessarily)

Appearance	Colorless to light yellow clear liquid
Odor	Odorless or characteristically mild
Nitrogen	7.8-8.6% min.
Specific Gravity（25℃）	1.14-1.17
pH	5.0-7.0
Total Solids	54-56%
As	0.001% max.
Pb	0.004% max.

 

PACKAGING

Standard packaging includes the following:

1.0kg/bottle; 10bottles/box

20kg net weight plastic pail

220kg net weight plastic drum

Other package sizes are available upon request.

 

STORAGE

Avoid freezing. Store at or near room temperature, out of direct sunlight. Keep containers tightly closed when not in use.

Storage at temperatures below 10°C for a long period of time, may cause formation of crystals, requires thawing and mixing prior to use, with no detrimental effect to product quality or efficacy.

 

PERIOD OF VALIDITY

24 months since the date of manufacture

 

PROPERTIES

Solubility

Very soluble in water; soluble in lower alcohols and glycols.

 

Antimicrobial Activity

SupGuard G is very effective against Gram-positive and Gram-negative bacteria, also provides some protection against yeasts and molds.

 

Toxicological Data

Acute oral toxicity LD50 (mice):	﹥2000mg/kg
Eye irritation (rabbits):	Non-irritating at 0.6% aqueous solution
Primary skin irritation (rabbits):	Non-irritating at 0.6% aqueous solution

 

Applications in Cosmetics

The active ingredient of SupGuard G, DMDM Hydantoin, is permitted for use in cosmetic and personal care products in the USA and the EU to a maximum concentration of 0.6%.

SupGuard G is compatible with essentially all cosmetic ingredients, such as surfactants, emulsifiers, proteins, aloe and amines. SupGuard G is an excellent preservative for both leave-on and rinse-off products such as shampoos, creams, lotions, bubble baths, rinses, wipes and towelettes. It is easy to handle, very stable and cost-effective. The recommended use level is 0.1～0.6% by weight of product as supplied.

 

SupGuard G exhibits an excellent synergistic preservative effect in combination with Iodopropynyl Butylcarbamate (IPBC), Parabens and Isothiazolinones. It is stable over a wide range of pH and temperature conditions. It does not discolor product when combined with additives or by changes in pH. It can be added at a wide range of temperatures from ambient to elevated 80℃.

 

 

SupGuard®  HG

INCI:	Sodium Hydroxymethylglycinate
CAS:	70161-44-3
EINECS:	274-357-8
Molecular Formula:	C3H6NO3Na
Molecular Weight:	127.07
Structural Formula:

 

 

 TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	Colorless to light yellow clear liquid
Odor	Characteristically mild
Nitrogen	5.4-6.0%
Specific Gravity(25℃)	1.27-1.30
pH	10.0-12.0
Total Solids	49-52%
As	0.0003% max.
Pb	0.001% max.

 

 

SupGuard®  NP-M

INCI:	Methylparaben
CAS:	99-76-3
EINECS:	202-785-7
Molecular Formula:	C8H8O3
Molecular Weight:	152.15
Structural Formula:

 

TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	White crystalline powder
Odor	Odorless or characteristically mild
Content	99.0% min.
Melting Point	125-128℃
Loss on Drying	0.5% max.
Residue on Ignition	0.1% max.
Acidity	Pass
Sulfate (based on SO42-)	0.024% max.
p-Hydroxybenzoic Acid and Salicylic Acid	Pass
As	0.0003% max.
Pb	0.001% max.

 

*Conforms to USP29 and Ph. Eur. 6.0

 

 

 

 

SupGuard®  IPBC-II

INCI:	Iodopropynyl Butylcarbamate
CAS:	55406-53-6
EINECS:	259-627-5
Molecular Formula:	C8H12INO2
Molecular Weight:	281.09
Structural Formula:

 

SupGuard® IPBC-II is one of the most advanced preservatives available to date. This is a newly patented (ZL200410090830.4) liquid product of Iodopropynyl Butylcarbamate (IPBC). It is water soluble and provides for easy addition of IPBC to a wider range of personal care formulations, especially high aqueous formulations, than ever before.

 

TYPICAL PROPERTIES (Not to be considered product specifications)

Appearance	Colorless to light yellow, clear viscous liquid at 25℃
Odor	Characteristically mild
Active Ingredient	5.8-6.2%
Specific Gravity(25℃)	1.10-1.13
As	0.0003% max.
Pb	0.001% max.
Stability	Soluble in ethanol, propylene glycol, polyethylene glycol and water.

 

 

SupGuard BN(Bronopol)

DESCRIPTION

 

INCI Adopted Name:	2-Bromo-2-Nitropropane-1,3-Diol
CAS Registry No.:	52-51-7
Molecular Formula:	C3H6BrNO4
Molecular Weight:	199.99

 

Like Product Name:

Bioban     Myacide

 

Structural Formula:   

 

 

SPECIFICATIONS (Not Necessarily)

Appearance	White or almost white crystalline powder
Odor	Odorless or almost odorless
Content	99.0% min.
Melting Point	125℃ min.
Free Bromine	0.3% max.
Loss on Drying	0.3% max.
Residue on Ignition	0.3% max.
As	0.001% max.
Pb	0.004% max.

 

PACKAGING

Standard packaging includes the following:

0.5kg/bottle; 20bottles/box

20 kg net weight cardboard drum inside plastic bag sealed

Other package sizes are available upon request.

 

STORAGE

Store in a well-ventilated, cool, dry area, out of direct sunlight. 
Keep containers tightly closed when not in use.

 

PERIOD OF VALIDITY

24 months since the date of manufacture

 

PROPERTIES

Solubility

Freely soluble in water and ethanol; slightly soluble in glycerin and liquid paraffin.

 

Antimicrobial Activity

SupGuard BN has extremely broad spectrum activity against Gram-positive and Gram-negative bacteria, 
yeasts and molds. It is particularly effective against Pseudomonas species.

 

Toxicological Data

Acute oral toxicity LD50 (mice):	266mg/kg(male),  222mg/kg (female)
Eye irritation (rabbits):	Slightly irritating at 0.5% aqueous solution; non-irritating at maximum use concentration of 0.1%
Primary skin irritation (rabbits):	Slightly irritating at 0.5% aqueous solution; non-irritating at maximum use concentration of 0.1%

 

Applications in Cosmetics

The active ingredient of SupGuard BN is 2-Bromo-2-Nitropropane-1,3-Diol or Bronopol. It is listed in the USA and the EU respectively as an approved cosmetic preservative at levels up to 0.1%.

SupGuard BN is an excellent preservative for both leave-on and rinse-off products such as creams, lotions, shampoos, rinses, wipes and towelettes. The recommended use level is 0.02～0.05%.

SupGuard BN is compatible with most cosmetic ingredients such as surfactants, emulsifiers, proteins and natural extracts. It is synergistic with other preservatives such as isothiazolinones, parabens and Iodopropynyl Butylcarbamate (IPBC). Its optimum pH range of use is 4～8. It should be added as the last ingredient and at the lowest temperature (≤50℃) if possible.

Conditions of high temperatures, alkaline and sunlight will cause degradation of the active ingredient. The presence of a few agents such as sulfhydryl compounds, sulfite, hyposulfite, aluminous and ferreous materials will lead to loss of activity. The use of secondary amines should be avoided in formulations.